Huu Trong Phan1,2, Dominic Lauzon2, Alexis Vallée-Bélisle2, Jeanne Leblond Chain3, Suzanne Giasson1,2
1) Faculty of Pharmacy, University of Montréal, C. P. 6128, Succursale Centre-ville, Montreal, QC H3C 3J7, Canada
2) Department of Chemistry, University of Montréal, C. P. 6128, Succursale Centre-ville, Montreal, QC H3C 3J7, Canada
3) INSERM, Bordeaux, France
The selectivity of interactions between functionalized nanoparticles and cell surfaces exhibiting different receptor densities plays an essential role in differentiating healthy cells from affected cells. We developed a nanoplatform based on gold nanoparticles functionalized with mixed polymer-brush layers (containing short functionalized chains and long non-functionalized chains) for a selective adsorption on receptor-functionalized surfaces. The effect of the molar ratio and the relative length of the polymers on the selectivity of nanoparticle/receptor surface interaction was investigated. We will show how the selectivity can be improved by adjusting these two parameters.